Recent Publications
Niu W, Lu D, Mojica-Perez SP, Tidball AM, Sudyk R, Stokes K, Parent JM. Abnormal Cell Sorting and Altered Early Neurogenesis in a Human Cortical Organoid Model of Protocadherin-19 Clustering Epilepsy. Front. Cell. Neurosci. 2024 Apr 4:18:1339345. PMCID: PMC11024992
Chen C, et al. Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B-linked developmental and epileptic encephalopathy. Brain Comm. 5:fcad283, Oct 20, 2023. PMCID: PMC10903178
Tidball AM, Niu W, Ma Q, Takla TN, Walker JC, Margolis JL, Mojica-Perez SP, Sudyk R, Deng L, Moore SJ, Chopra R, Shakkottai VG, Murphy GG, Yuan Y, Isom LL, Li JZ, Parent JM. Deriving early single-rosette brain organoids from human pluripotent stem cells. Stem Cell Rep. 18:2498-2514, 2023. PMCID:PMC10724074
Mojica-Perez SP, Stokes K, Jaklic DC, Jahagirdar S, Uhler M, Parent JM, Niu W. Efficient and precise single-cell clonal selection of human pluripotent stem cells. STAR Protoc. 4:102629, 2023. PMCID:PMC10565870
Kao H, Rao Y, Yang T, Ziobro J, Zylinski M, Mir M, Hu S, Cao R, Borna NN, Banerjee R, Parent J, Wang S, Leventhal D, Li P, Wang Y. Sudden Unexpected Death in Epilepsy and Respiratory Defects in a Mouse Model of DEPDC5-related Epilepsy. Ann. Neurol. 94:812-824, 2023. PMCID: PMC10592102
Takla TN, Luo J, Sudyk R, Huang J, Walker JC, Vora NL, Sexton JZ, Parent JM, Tidball AM. A shared pathogenic mechanism for valproic acid and SHROOM3 knockout in a brain organoid model of neural tube defects. Cells 12:1697, 2023. PMCID:PMC10340169
Palsamy K, Chen JY, Skaggs K,…Goldman D, Parent JM. Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia 71:2642-2663, 2023. PMCID:PMC10528132
Xu G, Mihaylova T, Li D, Tian F, Farrehi PM, Parent JM, Mashour GA, Wang MM, Borjigin J. Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human brain. Proc. Natl. Acad. Sci. U.S.A. 120:e2216268120, 2023. PMCID:PMC10175832
Deng L, Mojica-Perez SP, Azaria RD, Schultz M, Parent JM, Niu W. Loss of POGZ alters neural differentiation of human embryonic stem cells. Mol. Cell. Neurosci. 120:103727, 2022. PMCID:PMC9549529
Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. Identification of neural oscillations and epileptiform changes in human brain organoids. Nat Neurosci. 2021 Oct;24(10):1488-1500. doi: 10.1038/s41593-021-00906-5. PMID: 34426698.
Dang LT, Vaid S, Lin G, Swaminathan P, Safran J, Loughman A, Lee M, Glenn T, Majolo F, Crino PB, Parent JM. STRADA-mutant human cortical organoids model megalencephaly and exhibit delayed neuronal differentiation. Dev Neurobiol. 2021 Jul;81(5):696-709. doi: 10.1002/dneu.22816. Epub 2021 Apr 27. PubMed PMID: 33619909; PubMed Central PMCID: PMC8364481.
Tidball AM, Lopez-Santiago LF, Yuan Y, Glenn TW, Margolis JL, Clayton Walker J, Kilbane EG, Miller CA, Martina Bebin E, Scott Perry M, Isom LL, Parent JM. Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons. Brain. 2020 Oct 1;143(10):3025-3040. doi: 10.1093/brain/awaa247. PubMed PMID: 32968789; PubMed Central PMCID: PMC7780473.
Dang LT, Glanowska KM, Iffland Ii PH, Barnes AE, Baybis M, Liu Y, Patino G, Vaid S, Streicher AM, Parker WE, Kim S, Moon UY, Henry FE, Murphy GG, Sutton M, Parent JM, Crino PB. Multimodal Analysis of STRADA Function in Brain Development. Front Cell Neurosci. 2020;14:122. doi: 10.3389/fncel.2020.00122. eCollection 2020. PubMed PMID: 32457579; PubMed Central PMCID: PMC7227375.
Rodriguez CM, Wright SE, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, Parent JM, Rigo F, Barmada SJ, Todd PK. A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis. Nat Neurosci. 2020 Mar;23(3):386-397. doi: 10.1038/s41593-020-0590-1. Epub 2020 Feb 17. PubMed PMID: 32066985; PubMed Central PMCID: PMC7668390.
Lenk GM, Jafar-Nejad P, Hill SF, Huffman LD, Smolen CE, Wagnon JL, Petit H, Yu W, Ziobro J, Bhatia K, Parent J, Giger RJ, Rigo F, Meisler MH. Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome. Ann Neurol. 2020 Mar;87(3):339-346. doi: 10.1002/ana.25676. Epub 2020 Feb 6. PubMed PMID: 31943325; PubMed Central PMCID: PMC7064908.
Althaus AL, Moore SJ, Zhang H, Du X, Murphy GG, Parent JM. Altered Synaptic Drive onto Birthdated Dentate Granule Cells in Experimental Temporal Lobe Epilepsy. J Neurosci. 2019 Sep 18;39(38):7604-7614. doi: 10.1523/JNEUROSCI.0654-18.2019. Epub 2019 Jul 3. PubMed PMID: 31270158; PubMed Central PMCID: PMC6750946.
O'Malley HA, Hull JM, Clawson BC, Chen C, Owens-Fiestan G, Jameson MB, Aton SJ, Parent JM, Isom LL. Scn1b deletion in adult mice results in seizures and SUDEP. Ann Clin Transl Neurol. 2019 May 8;6(6):1121-1126. doi: 10.1002/acn3.785. PMID: 31211177
Bunton-Stasyshyn RK, et al. Prominent role of forebrain excitatory neurons in SCN8A encephalopathy. Brain 2019 Feb 1;142(2):362-375. doi: 10.1093/brain/awy324. PMCID: PMC6351781.
Frasier CR, Zhang H, Offord J, Dang LT, Auerbach DS, Shi H, Chen C, Goldman AM, Eckhardt LL, Bezzerides VJ, Parent JM, Isom LL. Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes. Stem Cell Reports. 2018 Sep 11;11(3):626-634. doi: 10.1016/j.stemcr.2018.07.012.
Hu S, Knowlton RC, Watson BO, Glanowska KM, Murphy GG, Parent JM, Wang Y. Somatic Depdc5 deletion recapitulates electroclinical features of human focal cortical dysplasia type IIA. Ann Neurol. 2018 Jul;84(1):140-146. doi: 10.1002/ana.25272.
Wang Y, Ji T, Nelson A, Glanowska K, Murphy GG, Jenkins PM, Parent JM. Critical roles of aII spectrin in brain development and epileptic encephalopathy. J. Clin. Invest. 128:760-773, 2018.
Zhao XF, Kohen R, Parent R, Duan Y, Fisher GL, Korn MJ, Ji L, Wan G, Jin J, Püschel AW, Dolan DF, Parent JM, Corfas G, Murphy GG, Giger RJ. PlexinA2 forward signaling through Rap1 GTPases regulates dentate gyrus development and schizophrenia-like behaviors. Cell Rep. 22:456-470, 2018.
Szabo GG, Oijala M, Varga C, Parent JM, Soltesz I. Extended interneuronal network of the dentate gyrus. Cell Rep. 20:1262-1268, 2017.
Tidball, A.M., Dang, L.T., Glenn, T.W., Kilbane, E.G., Klarr, D.J., Margolis, J.L., Uhler, M.D., Parent, J.M. Rapid generation of human genetic loss-of-function iPSC lines by simultaneous reprogramming and gene editing. Stem Cell Rep., 9:725-731, 2017.
Du, X., Zhang, H., Parent, J.M. Rabies tracing of birthdated dentate granule cells in rat temporal lobe epilepsy. Annals of Neurology (2017), 81:790-803.
For full publication list:
http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40458920/?sort=date&direction=descending
Chen C, et al. Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B-linked developmental and epileptic encephalopathy. Brain Comm. 5:fcad283, Oct 20, 2023. PMCID: PMC10903178
Tidball AM, Niu W, Ma Q, Takla TN, Walker JC, Margolis JL, Mojica-Perez SP, Sudyk R, Deng L, Moore SJ, Chopra R, Shakkottai VG, Murphy GG, Yuan Y, Isom LL, Li JZ, Parent JM. Deriving early single-rosette brain organoids from human pluripotent stem cells. Stem Cell Rep. 18:2498-2514, 2023. PMCID:PMC10724074
Mojica-Perez SP, Stokes K, Jaklic DC, Jahagirdar S, Uhler M, Parent JM, Niu W. Efficient and precise single-cell clonal selection of human pluripotent stem cells. STAR Protoc. 4:102629, 2023. PMCID:PMC10565870
Kao H, Rao Y, Yang T, Ziobro J, Zylinski M, Mir M, Hu S, Cao R, Borna NN, Banerjee R, Parent J, Wang S, Leventhal D, Li P, Wang Y. Sudden Unexpected Death in Epilepsy and Respiratory Defects in a Mouse Model of DEPDC5-related Epilepsy. Ann. Neurol. 94:812-824, 2023. PMCID: PMC10592102
Takla TN, Luo J, Sudyk R, Huang J, Walker JC, Vora NL, Sexton JZ, Parent JM, Tidball AM. A shared pathogenic mechanism for valproic acid and SHROOM3 knockout in a brain organoid model of neural tube defects. Cells 12:1697, 2023. PMCID:PMC10340169
Palsamy K, Chen JY, Skaggs K,…Goldman D, Parent JM. Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia 71:2642-2663, 2023. PMCID:PMC10528132
Xu G, Mihaylova T, Li D, Tian F, Farrehi PM, Parent JM, Mashour GA, Wang MM, Borjigin J. Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human brain. Proc. Natl. Acad. Sci. U.S.A. 120:e2216268120, 2023. PMCID:PMC10175832
Deng L, Mojica-Perez SP, Azaria RD, Schultz M, Parent JM, Niu W. Loss of POGZ alters neural differentiation of human embryonic stem cells. Mol. Cell. Neurosci. 120:103727, 2022. PMCID:PMC9549529
Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. Identification of neural oscillations and epileptiform changes in human brain organoids. Nat Neurosci. 2021 Oct;24(10):1488-1500. doi: 10.1038/s41593-021-00906-5. PMID: 34426698.
Dang LT, Vaid S, Lin G, Swaminathan P, Safran J, Loughman A, Lee M, Glenn T, Majolo F, Crino PB, Parent JM. STRADA-mutant human cortical organoids model megalencephaly and exhibit delayed neuronal differentiation. Dev Neurobiol. 2021 Jul;81(5):696-709. doi: 10.1002/dneu.22816. Epub 2021 Apr 27. PubMed PMID: 33619909; PubMed Central PMCID: PMC8364481.
Tidball AM, Lopez-Santiago LF, Yuan Y, Glenn TW, Margolis JL, Clayton Walker J, Kilbane EG, Miller CA, Martina Bebin E, Scott Perry M, Isom LL, Parent JM. Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons. Brain. 2020 Oct 1;143(10):3025-3040. doi: 10.1093/brain/awaa247. PubMed PMID: 32968789; PubMed Central PMCID: PMC7780473.
Dang LT, Glanowska KM, Iffland Ii PH, Barnes AE, Baybis M, Liu Y, Patino G, Vaid S, Streicher AM, Parker WE, Kim S, Moon UY, Henry FE, Murphy GG, Sutton M, Parent JM, Crino PB. Multimodal Analysis of STRADA Function in Brain Development. Front Cell Neurosci. 2020;14:122. doi: 10.3389/fncel.2020.00122. eCollection 2020. PubMed PMID: 32457579; PubMed Central PMCID: PMC7227375.
Rodriguez CM, Wright SE, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, Parent JM, Rigo F, Barmada SJ, Todd PK. A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis. Nat Neurosci. 2020 Mar;23(3):386-397. doi: 10.1038/s41593-020-0590-1. Epub 2020 Feb 17. PubMed PMID: 32066985; PubMed Central PMCID: PMC7668390.
Lenk GM, Jafar-Nejad P, Hill SF, Huffman LD, Smolen CE, Wagnon JL, Petit H, Yu W, Ziobro J, Bhatia K, Parent J, Giger RJ, Rigo F, Meisler MH. Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome. Ann Neurol. 2020 Mar;87(3):339-346. doi: 10.1002/ana.25676. Epub 2020 Feb 6. PubMed PMID: 31943325; PubMed Central PMCID: PMC7064908.
Althaus AL, Moore SJ, Zhang H, Du X, Murphy GG, Parent JM. Altered Synaptic Drive onto Birthdated Dentate Granule Cells in Experimental Temporal Lobe Epilepsy. J Neurosci. 2019 Sep 18;39(38):7604-7614. doi: 10.1523/JNEUROSCI.0654-18.2019. Epub 2019 Jul 3. PubMed PMID: 31270158; PubMed Central PMCID: PMC6750946.
O'Malley HA, Hull JM, Clawson BC, Chen C, Owens-Fiestan G, Jameson MB, Aton SJ, Parent JM, Isom LL. Scn1b deletion in adult mice results in seizures and SUDEP. Ann Clin Transl Neurol. 2019 May 8;6(6):1121-1126. doi: 10.1002/acn3.785. PMID: 31211177
Bunton-Stasyshyn RK, et al. Prominent role of forebrain excitatory neurons in SCN8A encephalopathy. Brain 2019 Feb 1;142(2):362-375. doi: 10.1093/brain/awy324. PMCID: PMC6351781.
Frasier CR, Zhang H, Offord J, Dang LT, Auerbach DS, Shi H, Chen C, Goldman AM, Eckhardt LL, Bezzerides VJ, Parent JM, Isom LL. Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes. Stem Cell Reports. 2018 Sep 11;11(3):626-634. doi: 10.1016/j.stemcr.2018.07.012.
Hu S, Knowlton RC, Watson BO, Glanowska KM, Murphy GG, Parent JM, Wang Y. Somatic Depdc5 deletion recapitulates electroclinical features of human focal cortical dysplasia type IIA. Ann Neurol. 2018 Jul;84(1):140-146. doi: 10.1002/ana.25272.
Wang Y, Ji T, Nelson A, Glanowska K, Murphy GG, Jenkins PM, Parent JM. Critical roles of aII spectrin in brain development and epileptic encephalopathy. J. Clin. Invest. 128:760-773, 2018.
Zhao XF, Kohen R, Parent R, Duan Y, Fisher GL, Korn MJ, Ji L, Wan G, Jin J, Püschel AW, Dolan DF, Parent JM, Corfas G, Murphy GG, Giger RJ. PlexinA2 forward signaling through Rap1 GTPases regulates dentate gyrus development and schizophrenia-like behaviors. Cell Rep. 22:456-470, 2018.
Szabo GG, Oijala M, Varga C, Parent JM, Soltesz I. Extended interneuronal network of the dentate gyrus. Cell Rep. 20:1262-1268, 2017.
Tidball, A.M., Dang, L.T., Glenn, T.W., Kilbane, E.G., Klarr, D.J., Margolis, J.L., Uhler, M.D., Parent, J.M. Rapid generation of human genetic loss-of-function iPSC lines by simultaneous reprogramming and gene editing. Stem Cell Rep., 9:725-731, 2017.
Du, X., Zhang, H., Parent, J.M. Rabies tracing of birthdated dentate granule cells in rat temporal lobe epilepsy. Annals of Neurology (2017), 81:790-803.
For full publication list:
http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40458920/?sort=date&direction=descending
