Parent Lab
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    • Denice Heckel
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    • Yu Liu
    • Louis Dang
    • Palsamy Kanagaraj
    • Sandra Mojica-Perez
    • Tuo Ji
    • Wei Niu
    • Tracy Qiao
    • Shivanshi Vaid
    • Isha Verma
    • Julie Ziobro
    • Carmen Varela
    • Kyle Stokes
    • Roksolana Sudyk
    • Jinghui Luo
    • Dan Jaklic
    • Sheetal Jahagirdar
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  • Home
  • Research
    • iPSC Models of Epilepsy
    • Rodent Models of Epilepsy and Stroke
    • Adult Neuroregeneration
  • People
    • Jack Parent
    • Denice Heckel
    • Andrew Tidball
    • Helen Zhang
    • Yu Liu
    • Louis Dang
    • Palsamy Kanagaraj
    • Sandra Mojica-Perez
    • Tuo Ji
    • Wei Niu
    • Tracy Qiao
    • Shivanshi Vaid
    • Isha Verma
    • Julie Ziobro
    • Carmen Varela
    • Kyle Stokes
    • Roksolana Sudyk
    • Jinghui Luo
    • Dan Jaklic
    • Sheetal Jahagirdar
    • Undergraduates
    • Former Lab Members
  • Publications
  • Collaborators
  • Contact
  • Blog

iPSC Models of Epilepsy

Part of the laboratory focuses on understanding epileptogenic mechanisms of genetic early infantile epileptic encephalopathies (EIEEs) using patient-derived cell generated from induced pluripotent stem cell (iPSCs). We generated one of the first patient-derived iPSC models of an EIEE, Dravet syndrome (DS), caused by mutations in the voltage-gated sodium channel alpha subunit gene SCN1A and associated with severe seizures, cognitive regression and a high incidence of SUDEP (Sudden Unexpected Death in Epilepsy). Using DS iPSC-derived neurons, we identified a novel potential epilepsy mechanism (Lu et al, 2013) and now have a platform to screen drugs for precision therapy. Similar iPSC modeling is ongoing in our lab for 8 other genetic epilepsies, including using cerebral organoid cultures, as well as studies of SUDEP using iPSC-derived cardiac myocytes from DS and SCN8A-Related EIEE. We are also part of an NIH U54 Epilepsy Centers Without Walls grant, entitled Epilepsy Multi-Platform Variant Prediction (EpiMVP), that aims to develop a tool to predict the pathogenicity of epilepsy gene variants of uncertain significance (VUS).


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Human iPSC-derived cortical projection neurons

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Human iPSC-derived cortical interneurons

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Human iPSC-derived cortical spheroid

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Human iPSC-derived cardiac myocytes (Huilin Shi)

Epilepsy Multi-Platform Variant Prediction (EpiMVP) Epilepsy Center Without Walls
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